Serum screening for Down's syndrome. ...but time consuming and expensive.

Anesthetic consideration in downs syndrome--a review.

Downs syndrome constitutes to be the most common chromosomal disorder. Patients with Downs's syndrome are posted for several surgeries including dental procedures and even for facial reconstruction. They are associated with several congenital anomalies in different organ system. There is also increased incidence of atlanto axial instability and risk of spinal cord injury. These children are sus...

Serum screening for Down's syndrome: some women's experiences.

OBJECTIVES To describe the experiences of a small group of women who had positive results after serum screening for Down's syndrome. DESIGN Semistructured telephone interviews and correspondence with women after a positive screening result (four women) negative amniocentesis results (eight), or termination of a pregnancy with a confirmed abnormality (eight). SUBJECTS 20 women who contacted ...

Choice of serum markers in antenatal screening for Down's syndrome.

How important is consent in maternal serum screening for Down syndrome in France? Information and consent evaluation in maternal serum screening for Down syndrome: a French study.

OBJECTIVES To evaluate the level of information and informed consent for maternal serum screening (MSS) for Down syndrome (DS) in the second trimester of pregnancy and analyse the exercise of autonomy towards the test by the women concerned. METHODS We studied the population of pregnant women attending obstetric consultations in two French hospitals over a 3-month period. The women were assig...

The Ups and Downs of BDNF in Rett Syndrome

Rett syndrome (RTT) is an X-linked postnatal neurodevelopmental disorder, which is primarily caused by mutations in the gene encoding methyl-CpG binding protein 2 (MeCP2). A number of MeCP2 target genes have been identified, including the neurotrophic factor BDNF; however, the functional relevance of these targets has not been established. In this issue of Neuron, Chang et al. provide the first...